Irregular Choice’s New Transformers Footwear and Purses Are More Than Meets the Eye

Prepare yourself for a journey back to 1984 as Hasbro teams up with Irregular Choice to unveil a TRANSFORMERS-inspired collection of footwear. As we approach TRANSFORMERS’ 40th anniversary in 2024, this 27-piece assortment of unisex shoes, bags, and accessories pays homage to the iconic Autobots and Decepticons that have been beloved for decades, including Optimus Prime, Bumblebee, Starscream, and Soundwave.

Here’s a sneak peek at the four vibrant pieces that were teased today!

MORE THAN MEETS THE EYE: These ankle boots take inspiration from the scheming Decepticon Starscream. They come with a detachable jet wing bearing the iconic Decepticon emblem. When transformed, these lightweight boots evoke a vibrant 80’s color palette!

AUTOBOT High-Heeled Boots: Elevate your style with these bold high-heeled Autobot boots in red and yellow, featuring a hidden platform and easy pull-on elasticated back for comfort and style on the go!

OPTIMUS PRIME BAG: This handbag puts Optimus Prime front and center with its vibrant colors and inspired detailing. When you carry this doctor-style bag down the street, there’s no doubt about which side you’re representing. It features snap closures, two internal pockets, and eye-catching contrasting lining.

MUSIC TO MY EARS BAG: Presenting a retro TRANSFORMERS bag, inspired by Soundwave, with versatile styling as a handbag or clutch. It features a glitter-filled gel pouch, cassette tape controls, and an 80’s arcade game pattern showcasing Autobot and Decepticon logos. Unsnap the magnetic popper to reveal plush orange lining and an inner pocket for convenience.

Mark your calendars for December 1, 2023, as this limited-edition collection will be available for purchase exclusively on the official Irregular Choice website. Whether you’re reliving your childhood or diving into the world of TRANSFORMERS for the first time, these eye-catching pieces are bound to be more than meets the eye!

What Makes Life Worth Living? The Ultimate Ethical Dilemma

Imagine a world where life depends on Nuronium for cognition, yet its source is compromised, risking extinction. Scientists propose an alternative energy source, Polixate, but it can’t sustain creativity and culture.

Is it extinction or life without culture? Can human existence truly be meaningful without creativity and culture? Join the debate in this captivating video as we puzzle through this classic ethical dilemma.

Watch now and share your thoughts on this fascinating question that challenges the very essence of our existence.

Pre-Order Google’s Pixel 8 Pro Smartphone, Get the New $350 Pixel Watch 2 for FREE

Looking to upgrade your smartphone? Here’s an offer you won’t want to miss! Google is currently offering the upcoming $350 Pixel Watch 2 for FREE when when you pre-order the new Pixel 8 Pro smartphone. Both devices are set for release next week, so if you pre-order now, you won’t have to wait for very long to get your new toys! And yes, this one is totally worth the upgrade!

Pre-Order: Google Pixel 8 Pro – Unlocked Android Smartphone + FREE $350 Pixel Watch 2

Please note that Geeks are Sexy might get a small commission from qualifying purchases done through our posts (as an Amazon associate or a member of other affiliate programs.)

Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave

Programmed cell death such as apoptosis is a common stage of cellular life. Nanoclustering/Science Photo Library via Getty Images

Zoie Magri, Tufts University

Living cells work better than dying cells, right? However, this is not always the case: your cells often sacrifice themselves to keep you healthy. The unsung hero of life is death.

While death may seem passive, an unfortunate ending that just “happens,” the death of your cells is often extremely purposeful and strategic. The intricate details of how and why cells die can have significant effects on your overall health.

There are over 10 different ways cells can “decide” to die, each serving a particular purpose for the organism. My own research explores how immune cells switch between different types of programmed death in scenarios like cancer or injury.

Programmed cell death can be broadly divided into two types that are crucial to health: silent and inflammatory.

Quietly exiting: silent cell death

Cells can often become damaged because of age, stress or injury, and these abnormal cells can make you sick. Your body runs a tight ship, and when cells step out of line, they must be quietly eliminated before they overgrow into tumors or cause unnecessary inflammation where your immune system is activated and causes fever, swelling, redness and pain.

Your body swaps out cells every day to ensure that your tissues are made up of healthy, functioning ones. The parts of your body that are more likely to see damage, like your skin and gut, turn over cells weekly, while other cell types can take months to years to recycle. Regardless of the timeline, the death of old and damaged cells and their replacement with new cells is a normal and important bodily process.

Silent cell death, or apoptosis, is described as silent because these cells die without causing an inflammatory reaction. Apoptosis is an active process involving many proteins and switches within the cell. It’s designed to strategically eliminate cells without alarming the rest of the body.

Sometimes cells can detect that their own functions are failing and turn on executioner proteins that chop up their own DNA, and they quietly die by apoptosis. Alternatively, healthy cells can order overactive or damaged neighbor cells to activate their executioner proteins.

Apoptosis is important to maintaining a healthy body. In fact, you can thank apoptosis for your fingers and toes. Fetuses initially have webbed fingers until the cells that form the tissue between them undergo apoptosis and die off.

Microscopy image of mouse foot at embryonic stage
The toes of this embryonic mouse foot are forming through apoptosis. Michal Maňas/Wikimedia Commons, CC BY-SA

Without apoptosis, cells can grow out of control. A well-studied example of this is cancer. Cancer cells are abnormally good at growing and dividing, and those that can resist apoptosis form very aggressive tumors. Understanding how apoptosis works and why cancer cells can disrupt it can potentially improve cancer treatments.

Other conditions can benefit from apoptosis research as well. Your body makes a lot of immune cells that all respond to different targets, and occasionally one of these cells can accidentally target your own tissues. Apoptosis is a crucial way your body can eliminate these immune cells before they cause unnecessary damage. When apoptosis fails to eliminate these cells, sometimes because of genetic abnormalities, this can lead to autoimmune diseases like lupus.

Another example of the role apoptosis plays in health is endometriosis, an understudied disease caused by the overgrowth of tissue in the uterus. It can be extremely painful and debilitating for patients. Researchers have recently linked this out-of-control growth in the uterus to dysfunctional apoptosis.

Whether it’s for development or maintenance, your cells are quietly exiting to keep your body happy and healthy.

Going out with a bang: inflammatory cell death

Sometimes, it is in your body’s best interest for cells to raise an alarm as they die. This can be beneficial when cells detect the presence of an infection and need to eliminate themselves as a target while also alerting the rest of the body. This inflammatory cell death is typically triggered by bacteria, viruses or stress.

Rather than quietly shutting down, cells undergoing inflammatory cell death will make themselves burst, or lyse, killing themselves and exploding inflammatory messengers as they go. These messengers tell your immune cells that there is a threat and prompts them to treat and fight the pathogen.

An inflammatory death would not be healthy for maintenance. If the normal recycling of your skin or gut cells caused an inflammatory reaction, you would feel sick a lot. This is why inflammatory death is tightly controlled and requires multiple signals to initiate.

Despite the riskiness of this grenadelike death, many infections would be impossible to fight without it. Many bacteria and viruses need to live around or inside your cells to survive. When specialized sensors on your cells detect these threats, they can simultaneously activate your immune system and remove themselves as a home for pathogens. Researchers call this eliminating the niche of the pathogen.

Cells die in many ways, including lysis.

Inflammatory cell death plays a major role in pandemics. Yersinia pestis, the bacteria behind the Black Death, has evolved various ways of stopping human immune cells from mounting a response. However, immune cells developed the ability to sense this trickery and die an inflammatory death. This ensures that additional immune cells will infiltrate and eliminate the bacteria despite the bacteria’s best attempts to prevent a fight.

Although the Black Death is not as common nowadays, close relatives Yersinia pseudotuberculosis and Yersinia enterocolitica are behind outbreaks of food-borne illnesses. These infections are rarely fatal because your immune cells can aggressively eliminate the pathogen’s niche by inducing inflammatory cell death. For this reason, however, Yersinia infection can be more dangerous in immunocompromised people.

The virus behind the COVID-19 pandemic also causes a lot of inflammatory cell death. Studies show that without cell death the virus would freely live inside your cells and multiply. However, this inflammatory cell death can sometimes get out of control and contribute to the lung damage seen in COVID-19 patients, which can greatly affect survival. Researchers are still studying the role of inflammatory cell death in COVID-19 infection, and understanding this delicate balance can help improve treatments.

In good times and bad, your cells are always ready to sacrifice themselves to keep you healthy. You can thank cell death for keeping you alive.The Conversation

Zoie Magri, Ph.D. Candidate in Immunology, Tufts University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Today’s Hottest Deals: Save BIG on 20000mAh Power Bank, Black Series Luke Skywalker Force FX Lightsaber, Cold Steel Training Sword, 70-inch Smart TV, and MORE!

For today’s edition of “Deal of the Day,” here are some of the best deals we stumbled on while browsing the web this morning! Please note that Geeks are Sexy might get a small commission from qualifying purchases done through our posts (as an Amazon associate or a member of other affiliate programs. As an Amazon Associate, I earn from qualifying purchases.)

LILIO 20000mAh Portable Power Bank with Digital Display$38.99 $15.99 (Clip Coupon at the Link!)

Get 3 Months FREE of Amazon Music Unlimited

INSIGNIA 70-inch Class F30 Series LED 4K UHD Smart Fire TV$599.99 $399.99

TOZO A1 Mini Wireless Earbuds Bluetooth 5.3 in Ear Light-Weight Headphones Built-in Microphone$29.99 $15.99 (Clip Coupon at the Link!)

STAR WARS The Black Series Luke Skywalker Force FX Elite Electronic Light-Saber with Advanced LED and Sound Effects$278.99 $199.00

Cold Steel Training Sword – Made of High-Impact Polypropylene$39.99 $19.59

Apple Watch Series 8 [GPS 41mm] Smart Watch w/Midnight Aluminum Case with Midnight Sport Band$399.00 $299.00

Microsoft Office Professional 2021 for Windows: Lifetime License$219.99 $32.97
Microsoft Office Home & Business for Mac 2021: Lifetime License$219.99 $32.97

Blink Video Doorbell (Black) + Mini Camera (Black) with Sync Module 2, Two-Way Audio, HD Video, Motion and Chime Alerts$129.97 $64.99

Amazon Smart Plug$24.99 $12.99

24-Pack: Rowdy Power Burn Energy Drinks$70 $24

Epic Halloween Light Show Sets the Night Ablaze to the Sound of ‘Toxicity’ (And MORE!)

Tom BetGeorge is back with his annual Halloween extravaganza, and this time, he’s set his home aglow with a fiery light show set to the hauntingly epic tune Toxicity. Check it out in the video above!

He also programmed another light show to Asking Alexandria’s When the Lights Come On.

[Via LS]